Andro NK

Natural Killer (NK) Cell Regulation

A powerful combination of nutrients and high potency herbal extracts that have been specifically tailored to boost immunity, and regulate cytokine levels and NK cell function, thereby reducing the severity and duration of the symptoms of viral infections. Important in Cancer protocols where chemotherapy is not applied.

Herbs and Nutrients that may Assist

Cat’s Claw (Uncaria tomentosa)

King of Bitters/Chiretta (Andrographis paniculata)

Wild Yam (Dioscorea villosa)

Zinc

Manganese

Vitamin E

Dosage: 2-6 tablets daily

Clinical Applications

Chronic infections:

Recurrent colds and ‘flu

Epstein-Barr Virus

Barmah Forest Virus

Ross River Virus

Cytomegalovirus

Herpes Virus

Human Immunodeficiency Virus

Etc.

Chronic Fatigue Syndrome

Any condition of reduced immune competence

Scientific Research

  • Andrographis paniculata, while widely used in traditional Ayurvedic medicine for infections and infestations, actually shows no antibacterial activity, - the evidence points instead to immune enhancing activity. It increases phagocytosis1, and both the antibody-specific and the non-specific immune responses. It has a demonstrable effect in reducing the symptoms of the common cold. It is also of equal or greater potency to St. Mary’s Thistle as a hepatoprotective and choleretic,,. Prior administration of Andrographis has prolonged survival after snakebite, and it has proven effective against nematodes such as Ascaris spp,. No toxicity has been recorded but it can reduce fertility,, and is thus contraindicated in pregnancy.
  • There are at least 13 related species of plant known as Cat’s Claw (Uņa de Gato in Spanish), but the major interest is in Uncaria tomentosa, a woody vine that grows to over 350 metres in length. The inner bark is traditionally used to treat an extraordinarily broad range of conditions: e.g. arthritis, gastritis, asthma, gastric ulcer, diabetes, cancers, viral infections, menstrual disorders, convalescence and debility. This capacity to treat such diverse conditions is in part explained by the discovery of immune-stimulating oxindole alkaloid constituents, the most active being isopteropodine. These have been found to stimulate phagocytosis14. Extracts of Cat’s Claw have demonstrated anti-inflammatory, antimutagenic, anticancer13 and antitumour13 activity. It has also been effective in the treatment of viral conditions, including herpes and HIV.
  • Wild Yam (Dioscorea villosa) is well known for its steroidal anti-inflammatory activity. Its inclusion stems from its lesser-known capacity to increase DHEA levels when these are depressed; for instance in chronic conditions like Chronic Fatigue Syndrome. It has no effect on persons with normal DHEA levels. DHEA is the hormonal precursor to testosterone and oestrogen derived from pregnenolone. Increased demand for cortisol (owing to stress, toxicity or infection) depletes pregnenolone, and hence DHEA. Dioscorea may exert a cortisol-sparing action via its anti-inflammatory action that in turn frees more pregnenolone for conversion to DHEA and the gonadal hormones.
  • Vitamin E and Manganese have both been shown to reduce excess inflammatory cytokine levels, thereby reducing the oxidative damage to lymphocytes (NK cells) and improving the clearance of infective agents.
  • Zinc in a specialised chelated form designed to enhance absorption has been shown to exert supportive actions on multiple pathways involved in the regulation of lymphocyte function.

References

1 Chang H M and But P P. Pharmacology and Applications of Chinese Materia Medica, Vol 2. World Scientific 1987.

2 Leelarasamee A et al. J Med Assoc Thailand. 1990; 73,299.

3 Puri A et al. J Natural Products. 1993; 56,995.

4 Melchior J, Palm S, Wikman G. Controlled clincial study of standardized Andrographis paniculata extract in common cold - a pilot trial. Phytomedicine. 1996/97; 3 (4): 315-318.

5 Tripathi G S and Tripathi Y B. Phytotherapy Res. 1991; 5,176.

6Shukla B et al. Plant Medica. 1992; 58,146.

7 Visen P K et al. J Ethnopharmacology. 1993; 40,131.

8Martz W. Toxicon. 1992; 30,1131.

9 Dutta A and Sukul N C. J Helminthology. 1982; 56,81.

10 Raj R K. Ind J Physiol Pharmacol. 1975; 19.

11Akbarsha M A et al. Ind J Exp Biol. 1990; 28,421.

12Zoha M S et al. Banglasdesh Med Res Council Bull. 1989; 15,34.

13 Blumenthal M. Una de Gato (Cat's Claw): Rainforest herb gets scientific and industry attention. Whole Foods (Herb Clip). 1995; 62-5.

14Wagner H, Kreutzkamp B, Jurcic K. The alkaloids of Uncaria tomentosa and their phagocytosis-stimulating action. Planta Medica. 1985; (5): 419-23.

15Senatore A et al. Phytochemical and biological study of Uncaria tomentosa. Bollettino - Societa Italiana Biologia Sperimentale. 1989; 65(6): 517-20.

16 Rizzi R et al. Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts. Journal of Ethnopharmacology. 1993; 38 (1): 63-77.

17 Steinberg P. Cat's Claw (una De Gato). The Herb Quarterly. 1994.

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